Association of circulating CEACAM1 levels and insulin sensitivity in gestational diabetes mellitus.

The aim of this study was to estimate the levels of circulating carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1) in subjects with gestational diabetes mellitus (GDM) and investigate the relationships between CEACAM1 and GDM. Circulating CEACAM1 levels were measured by ELISA kit in 70 women with GDM and 70 normal glucose tolerance (NGT) pregnant women. Blood samples were collected to detect fasting plasma glucose (FPG), fasting insulin (FINS) and glycosylated hemoglobin (HbA1c) levels in all participants. Insulin sensitivity index (ISOGTT) was calculated to assess insulin sensitivity.

Correlation analysis was performed between serum CEACAM1 levels and other parameters.Circulating CEACAM1 levels were higher in the GDM group than that in the NGT pregnant group, however, the difference showed no statistical significance (1889.82 ± 616.14 vs 1758.92 ± 433.15 pg/ml, p > 0.05). In GDM group, CEACAM1 was positively correlated with ISOGTT (R = 0.39, P = 0.001), while negatively with 1 h post-meal plasma insulin level (1hPINS) (R = -0.32, P = 0.008), 2 h post-meal plasma insulin level (2hPINS) (R = -0.33, P = 0.006) and area under curve of insulin (AUCI) (R = -0.36, P = 0.002) when adjusting for maternal age and gestational age.

The present study showed that circulating CEACAM1 levels did not differ in both GDM and NGT groups. However, we found a significant positively correlation between CEACAM1 and insulin sensitivity in the GDM group.

DACH1, a novel target of miR-218, participates in the regulation of cell viability, apoptosis, inflammatory response, and epithelial-mesenchymal transition process in renal tubule cells treated by high-glucose.

Objective: This report was designed to assess the functional role of miR-218/dachshund family transcription factor 1 (DACH1) in diabetic kidney disease (DKD) and investigate its possible molecular mechanism.Materials and Methods: From the GEO database, we downloaded different datasets for analyzing the expression of miR-218 and DACH1 in DKD. TargetScan was adopted to predict the binding sites between miR-218 and DACH1, which was further verified by dual-luciferase reporter assays. The renal proximal tubule cells (HK-2) treated with high glucose (HG) were used as an in vitro model.

QRT-PCR and western blot were used to determine the expression of DACH1 and other relative factors. Cell counting kit-8 and flow cytometer were applied to detect cell viability and apoptosis. The levels of inflammatory cytokines were determined by an ELISA assay.

NKG2D antibody

MBS837266-5x01mL 5x0.1mL
EUR 4655

NKG2D antibody (PE)

61R-1367 100 ug
EUR 415
Description: Rat monoclonal NKG2D antibody (PE)

NKG2D antibody (PE)

MBS834175-01mg 0.1mg
EUR 700

NKG2D antibody (PE)

MBS834175-5x01mg 5x0.1mg
EUR 3010

Human NKG2D Antibody

36795-05111 150 ug
EUR 215

CD314 (NKG2D) Antibody

abx201090-01mg 0.1 mg
EUR 477.6

NKG2D antibody (biotin)

61R-1605 100 ug
EUR 458
Description: Armenian Hamster monoclonal NKG2D antibody (biotin)

NKG2D antibody (biotin)

MBS834983-01mg 0.1mg
EUR 765

NKG2D antibody (biotin)

MBS834983-5x01mg 5x0.1mg
EUR 3285

NKG2D antibody (allophycocyanin)

61R-1778 100 ug
EUR 376
Description: Rat monoclonal NKG2D antibody (allophycocyanin)

NKG2D antibody (allophycocyanin)

MBS833721-005mg 0.05mg
EUR 640

NKG2D antibody (allophycocyanin)

MBS833721-01mg 0.1mg
EUR 1030

NKG2D antibody (allophycocyanin)

MBS833721-5x01mg 5x0.1mg
EUR 4475

CD314 (NKG2D) Antibody (PE)

abx201092-100tests 100 tests
EUR 927.6

CD314 (NKG2D) Antibody (APC)

abx201093-100tests 100 tests
EUR 828

CD314 (NKG2D) Antibody (FITC)

abx201091-100tests 100 tests
EUR 560.4

Anti-Human NKG2D Antibody

101-M585 100 µg
EUR 399
Description: NKG2D is a type II transmembrane protein with an extracellular C-type lectin domain. It occurs as a disulfide-linked homodimer that associates with either the DAP12 or DAP10 transmembrane adapter proteins. NKG2D is expressed on NK cells and some T cell subsets, where it functions as an activating receptor to trigger cytolytic activity and cytokine secretion. Ligands for human NKG2D include MICA, MICB, and ULBP-1, -2, -3, and -4. Mouse NKG2D ligands include H60, MULT-1, and Rae-1 alpha, beta, gamma, delta, and epsilon.

Anti-Mouse NKG2D Antibody

103-M441 100 µg
EUR 399
Description: NKG2D is a type II transmembrane protein with an extracellular C-type lectin domain. It occurs as a disulfide-linked homodimer that associates with either the DAP12 or DAP10 transmembrane adapter proteins. NKG2D is expressed on NK cells and some T cell subsets, where it functions as an activating receptor to trigger cytolytic activity and cytokine secretion. Ligands for human NKG2D include MICA, MICB, and ULBP-1, -2, -3, and -4. Mouse NKG2D ligands include H60, MULT-1, and Rae-1 alpha, beta, gamma, delta, and epsilon.

CD314 (NKG2D) Antibody (Biotin)

abx201094-01mg 0.1 mg
EUR 460.8

NKG2D Antibody HRP Conjugated

MBS9460103-01mL 0.1mL
EUR 595

NKG2D Antibody HRP Conjugated

MBS9460103-5x01mL 5x0.1mL
EUR 2525

NKG2D Antibody FITC Conjugated

MBS9460104-01mL 0.1mL
EUR 595

NKG2D Antibody FITC Conjugated

MBS9460104-5x01mL 5x0.1mL
EUR 2525

NKG2D Antibody FITC-Conjugated

MBS542219-01mg 0.1mg
EUR 560

NKG2D Antibody FITC-Conjugated

MBS542219-5x01mg 5x0.1mg
EUR 2380

NKG2D Antibody Affinity Purified

MBS540582-01mg 0.1mg
EUR 445

NKG2D Antibody Affinity Purified

MBS540582-5x01mg 5x0.1mg
EUR 1855

NKG2D Antibody BIOTIN-Conjugated

MBS542218-01mg 0.1mg
EUR 560

NKG2D Antibody BIOTIN-Conjugated

MBS542218-5x01mg 5x0.1mg
EUR 2380

NKG2D Polyclonal Antibody

MBS9237539-01mL 0.1mL
EUR 415

NKG2D Polyclonal Antibody

MBS9237539-5x01mL 5x0.1mL
EUR 1841

Anti-Mouse NKG2D Antibody (CX5)

MBS1569793-01mg 0.1mg
EUR 405

Anti-Mouse NKG2D Antibody (CX5)

MBS1569793-5x01mg 5x0.1mg
EUR 1520

Human NKG2D Antibody (Biotin Conjugate)

36795-05121 150 ug
EUR 315

NKG2D Antibody Antigenic Blocking Peptide

MBS544043-025mg 0.25mg
EUR 280

NKG2D Antibody Antigenic Blocking Peptide

MBS544043-5x025mg 5x0.25mg
EUR 1110

Anti-Mouse NKG2D Antibody (MI-6)

MBS1569792-01mg 0.1mg
EUR 405

Anti-Mouse NKG2D Antibody (MI-6)

MBS1569792-5x01mg 5x0.1mg
EUR 1520

NKG2D Polyclonal Conjugated Antibody

C46825 100ul
EUR 476.4

NKG2D Polyclonal Conjugated Antibody

MBS9454723-01mLAF350 0.1mL(AF350)
EUR 480

NKG2D Polyclonal Conjugated Antibody

MBS9454723-01mLAF405 0.1mL(AF405)
EUR 480

NKG2D Polyclonal Conjugated Antibody

MBS9454723-01mLAF488 0.1mL(AF488)
EUR 480

NKG2D Polyclonal Conjugated Antibody

MBS9454723-01mLAF555 0.1mL(AF555)
EUR 480

NKG2D Polyclonal Conjugated Antibody

MBS9454723-01mLBiotin 0.1mL(Biotin)
EUR 480

NKG2D Antibody Western Blot Positive Control

MBS542991-5Applications 5Applications
EUR 335

NKG2D Antibody Western Blot Positive Control

MBS542991-5x5Applications 5x5Applications
EUR 1350

NKG2D Ligand 2 (ULBP2) Antibody

20-abx142298
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  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 50 ul

NKG2D Ligand 2 (ULBP2) Antibody

20-abx005773
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  • Ask for price
  • Ask for price
  • Ask for price
  • 100 ul
  • 200 ul
  • 20 ul
  • 50 ul

NKG2D Ligand 2 (ULBP2) Antibody

abx029272-400ul 400 ul
EUR 627.6

NKG2D Ligand 2 (ULBP2) Antibody

abx029272-80l 80 µl
EUR 343.2

NKG2D Ligand 2 (ULBP2) Antibody

abx239250-100ug 100 ug
EUR 661.2

NKG2D Ligand 2 (ULBP2) Antibody

20-abx320552
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  • Ask for price
  • 100 ul
  • 50 ul

NKG2D Ligand 2 (ULBP2) Antibody

abx029272-400l 400 µl
EUR 518.75

NKG2D Ligand 2 (ULBP2) Antibody

abx239250-100l 100 µl Ask for price

NKG2D Ligand 2 (ULBP2) Antibody

abx239250-50l 50 µl
EUR 350

NKG2D Ligand 2 (ULBP2) Antibody

abx320552-100l 100 µl
EUR 350

NKG2D Ligand 2 (ULBP2) Antibody

abx320552-50l 50 µl
EUR 237.5

NKG2D Ligand 2 (ULBP2) Antibody

abx005773-100g 100 µg
EUR 175

Human CD314 (NKG2D) Monoclonal antibody

314B-01MG 0,1 mg
EUR 218.9

Rat Monoclonal anti-Mouse CD314 (NKG2D) Antibody

xAP-0620 100ug
EUR 280

NKG2D Polyclonal Antibody PE Conjugated

MBS9462367-01mL 0.1mL
EUR 595

NKG2D Polyclonal Antibody PE Conjugated

MBS9462367-5x01mL 5x0.1mL
EUR 2525

Mouse Monoclonal anti-Human CD314 (NKG2D) Antibody

xAP-0228 100ug
EUR 280

NKG2D Polyclonal Antibody Bio Conjugated

MBS9462366-01mL 0.1mL
EUR 595

NKG2D Polyclonal Antibody Bio Conjugated

MBS9462366-5x01mL 5x0.1mL
EUR 2525

NKG2-D Type II Integral Membrane Protein (NKG2D) Antibody

abx430571-200ul 200 ul
EUR 460.8

NKG2-D Type II Integral Membrane Protein (NKG2D) Antibody

abx430571-200l 200 µl
EUR 387.5

NKG2D

E8ER1913-86 100ul
EUR 275
Description: Available in various conjugation types.

NKG2D

MBS8578073-01mL 0.1mL
EUR 345

NKG2D

MBS8578073-01mLAF405L 0.1mL(AF405L)
EUR 565

NKG2D

MBS8578073-01mLAF405S 0.1mL(AF405S)
EUR 565

NKG2D

MBS8578073-01mLAF610 0.1mL(AF610)
EUR 565

NKG2D

MBS8578073-01mLAF635 0.1mL(AF635)
EUR 565

Human NKG2D AssayLite™ Antibody (RPE Conjugate)

36795-05151 5 x 30 ug
EUR 370

Human NKG2D AssayLite™ Antibody (APC Conjugate)

36795-05161 5 x 30 ug
EUR 370

Human NKG2D AssayLite™ Antibody (FITC Conjugate)

36795-05141 2 x 75 ug
EUR 370

Human NKG2D AssayLite™ Antibody (PerCP Conjugate)

36795-05171 5 x 30 ug
EUR 410

CD314 (NKG2D)

314A-100T 100 test
EUR 730.8

CD314 (NKG2D)

314F-100T 100 test
EUR 450

CD314 (NKG2D)

314PE-100T 100 test
EUR 840

CD314 (NKG2D)

314PU-01MG 0,1 mg
EUR 356.4

CD314 (NKG2D)

MO314B(V50) 50 ug
EUR 60

CD314 (NKG2D)

MO314F(V50) 50 ug
EUR 60

CD314 (NKG2D)

MO314PE(V50) 50 ug
EUR 60

Mouse Anti-Human NKG2D monoclonal antibody, clone 2E22

CABT-L1930 1 mg
EUR 748.13
Description: Mouse

NKG2D-IN-1

HY-155311 Get quote Ask for price
Description: NKG2D-IN-1 (compound 21) is a natural killer group 2D receptor (NKG2D) inhibitor with IC50s of 0.3 µM and 0.7 µM in NKG2D/MICA and ULBP6 TR-FRET assays, respectively[1].

NKG2D-IN-2

HY-155312 Get quote Ask for price
Description: NKG2D-IN-2 (compound 47) is a natural killer group 2D receptor (NKG2D) inhibitor with IC50s of 0.1 µM and 0.2 µM in NKG2D/MICA and ULBP6 TR-FRET assays, respectively[1].

NKG2D ligand 2

AP85547 1mg
EUR 2640

Armenian Hamster Anti-Mouse NKG2D Monoclonal antibody, clone HMG2D

CABT-L4409-1mg 1 mg
EUR 1076.4

Armenian Hamster Anti-Mouse NKG2D Monoclonal antibody, clone HMG2D

CABT-L4409-5mg 5 mg
EUR 2886

Armenian Hamster Anti-Mouse NKG2D Monoclonal antibody, clone HMG2D

CABT-L4409 1 mg; 5 mg Ask for price
Description: Armenian Hamster

KLRK1/CD314/NKG2D Rabbit anti-Human Polyclonal (C-Terminus) Antibody

MBS2402288-005mL 0.05mL
EUR 615

KLRK1/CD314/NKG2D Rabbit anti-Human Polyclonal (C-Terminus) Antibody

MBS2402288-5x005mL 5x0.05mL
EUR 2605

PE anti-mouse CD314 (NKG2D)

E16FMP314-050U 50 μg
EUR 433.33
Description: Available in various conjugation types.

PE anti-mouse CD314 (NKG2D)

E16FMP314-100U 100 μg
EUR 866.67
Description: Available in various conjugation types.

PE anti-mouse CD314 (NKG2D)

E16FMP314-200U 200 μg
EUR 1256.67
Description: Available in various conjugation types.

PE anti-human CD314 (NKG2D)

E16FHP314-025 25 tests
EUR 433.33
Description: Available in various conjugation types.

PE anti-human CD314 (NKG2D)

E16FHP314-100 100 tests
EUR 1256.67
Description: Available in various conjugation types.

Anti-Human CD314 (NKG2D) PE

MBS697097-100Tests 100Tests
EUR 450

Anti-Human CD314 (NKG2D) PE

MBS697097-25Tests 25Tests
EUR 250

Anti-Human CD314 (NKG2D) PE

MBS697097-5x100Tests 5x100Tests
EUR 1980

Anti-Mouse CD314 (NKG2D) PE

MBS697098-005mg 0.05mg
EUR 235

Anti-Mouse CD314 (NKG2D) PE

MBS697098-01mg 0.1mg
EUR 310

Anti-Mouse CD314 (NKG2D) PE

MBS697098-5x01mg 5x0.1mg
EUR 1355

APC anti-human CD314 (NKG2D)

E16FHA314-025 25 tests
EUR 541.67
Description: Available in various conjugation types.

APC anti-human CD314 (NKG2D)

E16FHA314-100 100 tests
EUR 975
Description: Available in various conjugation types.

APC anti-mouse CD314 (NKG2D)

E16FMA314-025U 25 μg
EUR 325
Description: Available in various conjugation types.

APC anti-mouse CD314 (NKG2D)

E16FMA314-050U 50 μg
EUR 650
Description: Available in various conjugation types.

APC anti-mouse CD314 (NKG2D)

E16FMA314-100U 100 μg
EUR 1126.67
Description: Available in various conjugation types.

FITC anti-mouse (CD314) NKG2D

E16FMF314-050U 50 μg
EUR 390
Description: Available in various conjugation types.

FITC anti-human CD314 (NKG2D)

E16FHF314-025 25 tests
EUR 498.33
Description: Available in various conjugation types.

FITC anti-human CD314 (NKG2D)

E16FHF314-100 100 tests
EUR 1061.67
Description: Available in various conjugation types.

Biotin anti-human CD314 (NKG2D)

E16FHB314-100U 100 μg
EUR 780
Description: Available in various conjugation types.

Biotin anti-mouse CD314 (NKG2D)

E16FMB314-050U 50 μg
EUR 346.67
Description: Available in various conjugation types.

Biotin anti-mouse CD314 (NKG2D)

E16FMB314-100U 100 μg
EUR 693.33
Description: Available in various conjugation types.

Purified anti-mouse CD314 (NKG2D)

E16FMU314-500U 500 μg
EUR 1083.33
Description: Available in various conjugation types.

Purified anti-human CD314 (NKG2D)

E16FHU314-100U 100 μg
EUR 433.33
Description: Available in various conjugation types.

Rat Monoclonal anti-mouse NKG2D

mAP-0293 100ug
EUR 250

Mouse Monoclonal anti-human NKG2D

hAP-0489 100ug
EUR 250

PE-Cy7 anti-human CD314 (NKG2D)

E16FHN314-025 25 tests
EUR 541.67
Description: Available in various conjugation types.

PE-Cy7 anti-human CD314 (NKG2D)

E16FHN314-100 100 tests
EUR 1148.33
Description: Available in various conjugation types.

NKG2D / KLRK1 Immunizing Peptide

MBS426409-01mg 0.1mg
EUR 225

NKG2D / CD314 Recombinant Protein

11-223 0.1 mg
EUR 651.3
Description: NKG2D is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors, also known as KLRK1, CD314, D12S2489E, KLR and killer cell lectin like receptor K1. NKG2D itself forms a homodimer whose ectodomains serve for ligand binding. NKG2D is a major recognition receptor for the detection and elimination of transformed and infected cells as its ligands are induced during cellular stress, either as a result of infection or genomic stress such as in cancer. In NK cells, NKG2D serves as an activating receptor, which itself is able to trigger cytotoxicity. The function of NKG2D on CD8+ T cells is to send co-stimulatory signals to activate them.

NKG2D / CD314 Recombinant Protein

11-282 0.1 mg
EUR 651.3
Description: NKG2D is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors, also known as KLRK1, CD314, D12S2489E, KLR and killer cell lectin like receptor K1. NKG2D itself forms a homodimer whose ectodomains serve for ligand binding. NKG2D is a major recognition receptor for the detection and elimination of transformed and infected cells as its ligands are induced during cellular stress, either as a result of infection or genomic stress such as in cancer. In NK cells, NKG2D serves as an activating receptor, which itself is able to trigger cytotoxicity. The function of NKG2D on CD8+ T cells is to send co-stimulatory signals to activate them.

NKG2D / CD314 Recombinant Protein

11-299 0.1 mg
EUR 651.3
Description: NKG2D is a transmembrane protein belonging to the CD94/NKG2 family of C-type lectin-like receptors, also known as KLRK1, CD314, D12S2489E, KLR and killer cell lectin like receptor K1. NKG2D itself forms a homodimer whose ectodomains serve for ligand binding. NKG2D is a major recognition receptor for the detection and elimination of transformed and infected cells as its ligands are induced during cellular stress, either as a result of infection or genomic stress such as in cancer. In NK cells, NKG2D serves as an activating receptor, which itself is able to trigger cytotoxicity. The function of NKG2D on CD8+ T cells is to send co-stimulatory signals to activate them.

NE Purified anti-mouse CD314 (NKG2D)

E16FMY314-500U 500 μg
EUR 1126.67
Description: Available in various conjugation types.

PerCP-Cy5.5 anti-human CD314 (NKG2D)

E16FHS314-025 25 tests
EUR 498.33
Description: Available in various conjugation types.

PerCP-Cy5.5 anti-human CD314 (NKG2D)

E16FHS314-100 100 tests
EUR 1278.33
Description: Available in various conjugation types.

NE Purified anti-human CD314 (NKG2D)

E16FHY314-050U 50 μg
EUR 498.33
Description: Available in various conjugation types.

NE Purified anti-human CD314 (NKG2D)

E16FHY314-500U 500 μg
EUR 1061.67
Description: Available in various conjugation types.

UNE Purified anti-human CD314 (NKG2D)

E16FHZ314-1000U 1 mg
EUR 2795
Description: Available in various conjugation types.

Human NKG2D / CD314, Fc Tag

E24PHA192 50 μg
EUR 200

NKG2D, Avi-Tag, Fc fusion

100252 100 µg
EUR 320
Description: Human NKG2d, also known as, Killer Cell Lectin Like Receptor K1, KLRK1, and NK Cell Receptor D. GenBank Accession No. NM_007360.4, a.a. 38-216, with an N-terminal Avi-Tag™ fused to the Fc portion of human IgG1 and expressed in a HEK293 cell expression system. MW=53 kDa.

Human NKG2D / CD314, His Tag

E24PHA193 50 μg
EUR 262

Human NKG2D Protein, mFc Tag

E33P100079 10 μg
EUR 225

Human NKG2D Protein, mFc Tag

MBS8575114-001mg 0.01mg
EUR 305

Human NKG2D Protein, mFc Tag

MBS8575114-5x001mg 5x0.01mg
EUR 1220

Mouse NKG2D Protein, hFc Tag

MBS189277-001mg 0.01mg
EUR 260

Mouse NKG2D Protein, hFc Tag

MBS189277-005mg 0.05mg
EUR 545

Mouse NKG2D Protein, hFc Tag

MBS189277-5x005mg 5x0.05mg
EUR 2160

Hamster monoclonal anti-mouse CD314 (NKG2D)

gAP-0033 1mg
EUR 450

Recombinant Mouse NKG2D/CD314 Protein

RP02720 1000μg
EUR 731.25

Human NKG2D ligand 2 ELISA Kit

EK4447 96 tests
EUR 599

Human NKG2D ligand 2 ELISA Kit

MBS761361-10x96StripWells 10x96-Strip-Wells
EUR 3900

Human NKG2D ligand 2 ELISA Kit

MBS761361-48StripWells 48-Strip-Wells
EUR 340

Human NKG2D ligand 2 ELISA Kit

MBS761361-5x96StripWells 5x96-Strip-Wells
EUR 2045

Human NKG2D ligand 2 ELISA Kit

MBS761361-96StripWells 96-Strip-Wells
EUR 455

Human NKG2D ligand 2 ELISA Kit

MBS2880120-10x96StripWells 10x96-Strip-Wells
EUR 4080

Human NKG2D ligand 2 ELISA Kit

MBS2880120-48StripWells 48-Strip-Wells
EUR 390

Human NKG2D ligand 2 ELISA Kit

MBS2880120-5x96StripWells 5x96-Strip-Wells
EUR 2220

Human NKG2D ligand 2 ELISA Kit

MBS2880120-96StripWells 96-Strip-Wells
EUR 520

Human NKG2D ligand 2 ELISA Kit

MBS9428273-5x96Tests 5x96Tests
EUR 2820

Human NKG2D ligand 2 ELISA Kit

MBS9428273-96Tests 96Tests
EUR 615

Recombinant Cynomolgus NKG2D, His-tagged

NKG2D-8845C 50 µg
EUR 478.4
Description: Store it under sterile conditions at -70℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

Human NKG2D / CD314 Protein, His Tag

NKD-H5245 100ug
EUR 2471.7
Description: Human NKG2D, His Tag (NKD-H5245) is expressed from human 293 cells (HEK293). It contains AA Ile 73 - Val 216 (Accession # P26718-1).

Rat Anti-Mouse CD314 (NKG2D) Purified (50 ug)

TA320405 50 µg Ask for price

Rat soluble NKG2D ligands ELISA kit

E02N0038-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Rat soluble NKG2D ligands in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat soluble NKG2D ligands ELISA kit

E02N0038-48 1 plate of 48 wells
EUR 624
Description: A competitive ELISA for quantitative measurement of Rat soluble NKG2D ligands in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Rat soluble NKG2D ligands ELISA kit

E02N0038-96 1 plate of 96 wells
EUR 822
Description: A competitive ELISA for quantitative measurement of Rat soluble NKG2D ligands in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Pig soluble NKG2D ligands ELISA kit

E07N0038-192T 192 tests
EUR 1524
Description: A competitive ELISA for quantitative measurement of Porcine soluble NKG2D ligands in samples from blood, plasma, serum, cell culture supernatant and other biological fluids. This is a high quality ELISA kit developped for optimal performance with samples from the particular species.

Results: A prominent raise of miR-218 was observed in DKD through bioinformatics analysis, which was further confirmed in the HG-induced model. DACH1 is a target of miR-218. miR-218 reduced cell viability and induced apoptosis by negatively regulating DACH1. Moreover, upregulating miR-218 in HG models increased the concentrations of pro-inflammatory cytokines TNF-α and IL-1β, reduced the level of anti-inflammatory cytokine IL-10, and promoted the epithelial-mesenchymal transition (EMT) process, which is possibly achieved by targeting DACH1.

While downregulating miR-218 showed the opposite results.Conclusion: These data demonstrated that, under an in vitro HG environment, miR-218 suppressed the HK-2 cells proliferation, promoted apoptosis, caused an inflammatory response, and facilitated the EMT process largely by targeting DACH1, providing an insight into the therapeutic intervention of DKD.